My Primary Care Doctor consulted with a headache specialist. The nurse taught me the difference between Prevention and Acute Treatment for migraine… My preventive treatment I take on a regular basis to reduce the number of migraines I have. My acute treatment… I only take when a migraine comes on. Two initial preventive treatments did not work, but now I take a shot every three months which has worked. Rarely do I take my acute medication, but when I do I try to take it early… right when I feel a headache coming on.